Anti-CXCL11 Antibody

Rs. 61,689.00
SKU stj23299

General Information

Product name Anti-CXCL11 Antibody
Short Description Rabbit polyclonal to CXCL11
Description Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-CXCL11 Antibody
Immunogen A synthetic peptide of human CXCL11
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 10.4 kDa
Database Links
Alternative Names CXCL11C-X-C motif chemokine 11 antibodyBeta-R1 antibodyH174 antibodyInterferon gamma-inducible protein 9 antibodyIP-9 antibodyInterferon-inducible T-cell alpha chemoattractant antibodyI-TAC antibodySmall-inducible cytokine B11CXCL11 antibodyITAC antibodySCYB11 antibodySCYB9B
Function Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes, Induces calcium release in activated T-cells, Binds to CXCR3, May play an important role in CNS diseases which involve T-cell recruitment, May play a role in skin immune responses
Cellular Localization Secreted
Tissue Specificity High levels in peripheral blood leukocytes, pancreas and liver astrocytes, moderate levels in thymus, spleen and lung, low levels in placenta, prostate and small intestine, also found in epidermal basal layer keratinocytes in skin disorders
Swiss-Prot Key

 

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