Anti-CXCR3 Antibody

Rs. 45,619.00
SKU stj23303

General Information

Product name Anti-CXCR3 Antibody
Short Description Rabbit polyclonal to CXCR3
Description This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-CXCR3 Antibody
Immunogen A synthetic peptide of human CXCR3
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 40.7 kDa
Database Links
Alternative Names CXCR3C-X-C chemokine receptor type 3 antibodyCXC-R3 antibodyCXCR-3 antibodyCKR-L2 antibodyG protein-coupled receptor 9 antibodyInterferon-inducible protein 10 receptor antibodyIP-10 receptor antibodyCD antigen CD183CXCR3 antibodyGPR9
Function Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway , Does not promote cell chemotaxis respons, Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis, Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
Cellular Localization Cell membrane
Tissue Specificity Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle, isoform 1 is also expressed in placenta, isoform 2 is expressed in endothelial cells, expressed in t-cells (at protein level).
Swiss-Prot Key

 

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