Anti-CXCR4 Antibody

Rs. 45,619.00
SKU stj23304

General Information

Product name Anti-CXCR4 Antibody
Short Description Rabbit polyclonal to CXCR4
Description This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-CXCR4 Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CXCR4 (NP_003458.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39.7 kDa
Database Links
Alternative Names CXCR4C-X-C chemokine receptor type 4 antibodyCXC-R4 antibodyCXCR-4 antibodyFB22 antibodyFusin antibodyHM89 antibodyLCR1 antibodyLeukocyte-derived seven transmembrane domain receptor antibodyLESTR antibodyLipopolysaccharide-associated protein 3 antibodyLAP-3 antibodyLPS-associated protein 3 antibodyNPYRL antibodyStromal cell-derived factor 1 receptor antibodySDF-1 receptor antibodyCD antigen CD184CXCR4
Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation, Acts as a receptor for extracellular ubiquitin
Cellular Localization Cell membrane
Tissue Specificity Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells, isoform 1 is predominant in all tissues tested.
Swiss-Prot Key

 

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