Anti-Cyclin C antibody

Rs. 50,211.00
SKU stj92536

General Information

Product name Anti-Cyclin C antibody
Short Description
Description Rabbit polyclonal to Cyclin C.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:5000
Protein Name Anti-Cyclin C antibody
Immunogen Synthesized peptide derived from human Cyclin C around the non-phosphorylation site of S275.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 42 kDa
Database Links
Alternative Names Cyclin-C antibody
SRB11 homolog antibody
hSRB11 antibody
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Cellular Localization Nucleus
Tissue Specificity Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Swiss-Prot Key

 

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