Anti-CYLD Antibody

Rs. 45,619.00
SKU stj23310

General Information

Product name Anti-CYLD Antibody
Short Description Rabbit polyclonal to CYLD
Description This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Anti-CYLD Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 654-953 of human CYLD (NP_001035877.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 107.3 kDa
Database Links
Alternative Names CYLDUbiquitin carboxyl-terminal hydrolase CYLD CYLD antibodyCYLD1 antibodyKIAA0849 antibodyHSPC057
Function Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains, Has endodeubiquitinase activity, Plays an important role in the regulation of pathways leading to NF-kappa-B activation.
Cellular Localization Cytoplasm, Cytoplasm, perinuclear region, Cytoplasm, cytoskeleton, Cell membrane
Tissue Specificity Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung, isoform 2 is found in all tissues except kidney.
Swiss-Prot Key

 

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