Anti-CYP1A1 Antibody

Rs. 45,619.00
SKU stj23316

General Information

Product name Anti-CYP1A1 Antibody
Short Description Rabbit polyclonal to CYP1A1
Description This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CYP1A1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human CYP1A1 (NP_000490.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 58.2 kDa
Database Links
Alternative Names CYP1A1Cytochrome P450 1A1 CYP1A1
Function Cytochromes P450 are a group of heme-thiolate monooxygenases, In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway, It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Lung, lymphocytes and placenta
Swiss-Prot Key

 

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