Anti-CYP1A2 Antibody

Rs. 45,619.00
SKU stj23317

General Information

Product name Anti-CYP1A2 Antibody
Short Description Rabbit polyclonal to CYP1A2
Description This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CYP1A2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 205-305 of human CYP1A2 (NP_000752.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 58.4 kDa
Database Links
Alternative Names CYP1A2Cytochrome P450 1A2 CYP1A2
Function Cytochromes P450 are a group of heme-thiolate monooxygenases, In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway, It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics, Most active in catalyzing 2-hydroxylation, Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation, Also acts in the metabolism of aflatoxin B1 and acetaminophen, Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines, Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Liver
Swiss-Prot Key

 

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