Anti-CYP3A4 Antibody

Rs. 45,619.00
SKU stj115444

General Information

Product name Anti-CYP3A4 Antibody
Short Description Rabbit polyclonal to CYP3A4
Description This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Cytochrome P450 3A4
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 57.3 kDa
Database Links
Alternative Names CYP3A4Cytochrome P450 3A4 CYP3A4 antibodyCYP3A3
Function Cytochromes P450 are a group of heme-thiolate monooxygenases, In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway, It performs a variety of oxidation reactions (e,g, caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics, Acts as a 1,8-cineole 2-exo-monooxygenase, The enzyme also hydroxylates etoposide.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Expressed in prostate and liver, according to some authors, it is not expressed in brain.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF