Anti-CYSLTR1 Antibody

Rs. 45,619.00
SKU stj117786

General Information

Product name Anti-CYSLTR1 Antibody
Short Description Rabbit polyclonal to CYSLTR1
Description This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Cysteinyl leukotriene receptor 1CysLTR1Cysteinyl leukotriene D4 receptorLTD4 receptorG-protein coupled receptor HG55HMTMF81
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYSLTR1 (NP_006630.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.5 kDa
Database Links
Alternative Names CYSLTR1Cysteinyl leukotriene receptor 1 antibodyCysLTR1 antibodyCysteinyl leukotriene D4 receptor antibodyLTD4 receptor antibodyG-protein coupled receptor HG55 antibodyHMTMF81CYSLTR1 antibodyCYSLT1
Function Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma, Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung, This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system, The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4
Cellular Localization Cell membrane
Tissue Specificity Widely expressed, with highest levels in spleen and peripheral blood leukocytes, lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart
Swiss-Prot Key

 

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