Anti-DAZ1 Antibody

Rs. 45,619.00
SKU stj27263

General Information

Product name Anti-DAZ1 Antibody
Short Description Rabbit polyclonal to DAZ1
Description This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-DAZ1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 340-530 of human DAZ1 (NP_004072.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 82.8 kDa
Database Links
Alternative Names DAZ1Deleted in azoospermia protein 1DAZ1 antibodyDAZ antibodySPGY
Function RNA-binding protein that plays an essential role in spermatogenesis, May act by binding to the 3'-UTR of mRNAs and regulating their translation, Promotes germ-cell progression to meiosis and formation of haploid germ cells.
Cellular Localization Cytoplasm.
Tissue Specificity Testis-specific, expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level).
Swiss-Prot Key

 

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