Anti-DCAMKL2 antibody

Rs. 50,211.00
SKU stj92663

General Information

Product name Anti-DCAMKL2 antibody
Short Description Rabbit polyclonal to DCAMKL2.
Description DCAMKL2 is a protein encoded by the DCLK2 gene which is approximately 83,6 kDa. DCAMKL2 is localised to the cytoplasm and is involved in transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. This protein falls under the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization. It also contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase. DCAMKL2 is expressed in the brain, heart and eye. The absence of this protein results in a severe epileptic phenotype and lethality. stj92663 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of DCAMKL2 protein.
Applications WB,IF,ELISA
Dilution range WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-DCAMKL2 antibody
Immunogen Synthesized peptide derived from human DCAMKL2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 83 kDa
Database Links
Alternative Names Serine/threonine-protein kinase DCLK2 antibody
CaMK-like CREB regulatory kinase 2 antibody
CL2 antibody
CLICK-II antibody
CLICK2 antibody
Doublecortin domain-containing protein 3B antibody
Doublecortin-like and CAM kinase-like 2 antibody
Doublecortin-like kinase 2 antibody
DCDC3B antibody
DCK2 antibody
Function Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm .
Cellular Localization Cytoplasm, cytoskeleton. Colocalizes with microtubules.
Tissue Specificity Expressed in the brain, heart and eyes.
Swiss-Prot Key

 

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