Anti-DCD Antibody

Rs. 45,619.00
SKU stj29419

General Information

Product name Anti-DCD Antibody
Short Description Rabbit polyclonal to DCD
Description This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-DCD Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human DCD (NP_444513.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 11.3 kDa
Database Links
Alternative Names DCDDermcidinDCD antibodyAIDD antibodyDSEP
Function DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization, Highly effective against E,coli, E,faecalis, S,aureus and C,albicans, Optimal pH and salt concentration resemble the conditions in sweat, Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues.
Cellular Localization Secreted
Tissue Specificity Specifically and constitutively expressed in eccrine sweat gland cells, secreted into the sweat at a concentration of 1-10 micrograms/ml
Swiss-Prot Key

 

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