Anti-DDB1 Antibody

Rs. 68,577.00
SKU stj70011

General Information

Product name Anti-DDB1 Antibody
Short Description Goat polyclonal to DDB1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-DDB1 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 127 kDa
Database Links
Alternative Names DDB1DNA damage-binding protein 1 antibodyDDB p127 subunit antibodyDNA damage-binding protein a antibodyDDBa antibodyDamage-specific DNA-binding protein 1 antibodyHBV X-associated protein 1 antibodyXAP-1 antibodyUV-damaged DNA-binding factor antibodyUV-damaged DNA-binding protein 1 antibodyUV-DDB 1 antibodyXPE-binding factor antibodyXPE-BF antibodyXeroderma pigmentosum group E-complementing protein antibodyXPCeDDB1 antibodyXAP1
Function Required for DNA repair, Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex), The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair, The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches, Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1, DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage, The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair, DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER, DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication, DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR), May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2,
Cellular Localization Cytoplasm, Nucleus,
Tissue Specificity
Swiss-Prot Key

 

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