Anti-DDR1 antibody

Rs. 50,211.00
SKU stj92673

General Information

Product name Anti-DDR1 antibody
Short Description
Description Rabbit polyclonal to DDR1.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-DDR1 antibody
Immunogen Synthesized peptide derived from human CD167a around the non-phosphorylation site of Y792.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 100 kDa
Database Links
Alternative Names Epithelial discoidin domain-containing receptor 1 antibody
Epithelial discoidin domain receptor 1 antibody
CD167 antigen-like family member A antibody
Cell adhesion kinase antibody
Discoidin receptor tyrosine kinase antibody
HGK2 antibody
Mammary carcinoma kinase 10 antibody
MCK-10 antibody
Protein-tyrosine kinase 3A antibody
Protein-tyrosine kinase RTK-6 antibody
TRK E antibody
Tyrosine kinase DDR antibody
Tyrosine-protein kinase CAK antibody
CD antigen CD167a antibody
CAK antibody
EDDR1 antibody
NEP antibody
NTRK4 antibody
PTK3A antibody
RTK6 antibody
TRKE antibody
Function Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing . Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Cellular Localization Isoform 1: Cell membrane. Single-pass type I membrane protein.. Isoform 2: Cell membrane. Single-pass type I membrane protein.. Isoform 3: Secreted Isoform 4: Cell membrane. Single-pass type I membrane protein.
Tissue Specificity Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
Swiss-Prot Key

 

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