Anti-DDX1 Antibody

Rs. 45,619.00
SKU stj28658

General Information

Product name Anti-DDX1 Antibody
Short Description Rabbit polyclonal to DDX1
Description DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.
Applications WB,IHC,IF,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100
IP 1:20 - 1:50
Protein Name Anti-DDX1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 441-740 of human DDX1 (NP_004930.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 82.4 kDa
Database Links
Alternative Names DDX1ATP-dependent RNA helicase DDX1 DDX1
Function Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes, Possesses 5' single-stranded RNA overhang nuclease activity, Possesses ATPase activity on various RNA, but not DNA polynucleotides, May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome, Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation, Acts as a positive transcriptional regulator of cyclin CCND2 expression, Binds to the cyclin CCND2 promoter region, Associates with chromatin at the NF-kappa-B promoter region via association with RELA, Binds to poly(A) RNA, May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs, Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation Required for Coronavirus IBV replication.
Cellular Localization Nucleus, Cytoplasm, Cytoplasmic granule.
Tissue Specificity Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord.
Swiss-Prot Key

 

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