Anti-DDX3X Antibody

Rs. 45,619.00
SKU stj27604

General Information

Product name Anti-DDX3X Antibody
Short Description Rabbit polyclonal to DDX3X
Description The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-DDX3X Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human DDX3X (NP_001347.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 73.2 kDa
Database Links
Alternative Names DDX3XATP-dependent RNA helicase DDX3X DDX3X antibodyDBX antibodyDDX3
Function Multifunctional ATP-dependent RNA helicase, The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity, In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs, Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation, However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs, Involved in transcriptional regulation, Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner, Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter, Involved in regulation of translation initiation, Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs
Cellular Localization Nucleus speckle, Cytoplasm, Mitochondrion outer membrane.
Tissue Specificity
Swiss-Prot Key

 

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