Anti-DDX58 Antibody

Rs. 68,577.00
SKU stj73481

General Information

Product name Anti-DDX58 Antibody
Short Description Goat polyclonal to DDX58
Description
Applications ELISA, FC, IF, IHC
Dilution range
Protein Name Anti-DDX58 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 106.6 kDa
Database Links
Alternative Names DDX58Probable ATP-dependent RNA helicase DDX58 DDX58
Function Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines, Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length), In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential, Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity, A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity, Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs)
Cellular Localization Cytoplasm, Cell projection, ruffle membrane, Cytoplasm, cytoskeleton, Cell junction, tight junction,
Tissue Specificity Present in vascular smooth cells (at protein level),
Swiss-Prot Key

 

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