General Information
| Product name | Anti-DEFA3 Antibody |
|---|---|
| Short Description | Rabbit polyclonal to DEFA3 |
| Description | Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. |
| Applications | WB |
| Dilution range | WB 1:500 - 1:2000 |
| Protein Name | Anti-DEFA3 Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20-94 of human DEFA3 (NP_005208.1). |
| Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgG |
| Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 10.2 kDa |
| Database Links | |
| Alternative Names | DEFA3Neutrophil defensin 3 antibodyDefensin antibodyalpha 3 antibodyHNP-3 antibodyHP-3 antibodyHP3DEFA3 antibodyDEF3 |
| Function | Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities, Has antimicrobial activity against Gram-negative and Gram-positive bacteria, Defensins are thought to kill microbes by permeabilizing their plasma membrane. |
| Cellular Localization | Secreted |
| Tissue Specificity | |
| Swiss-Prot Key |