Anti-DFFA Antibody

Rs. 45,619.00
SKU stj29835

General Information

Product name Anti-DFFA Antibody
Short Description Rabbit polyclonal to DFFA
Description Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-DFFA Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human DFFA (NP_004392.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.5 kDa
Database Links
Alternative Names DFFADNA fragmentation factor subunit alpha antibodyDNA fragmentation factor 45 kDa subunit antibodyDFF-45 antibodyInhibitor of CAD antibodyICADDFFA antibodyDFF1 antibodyDFF45 antibodyH13
Function Inhibitor of the caspase-activated DNase (DFF40)
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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