Anti-DGCR8 Antibody

Rs. 50,211.00
SKU stj27815

General Information

Product name Anti-DGCR8 Antibody
Short Description Rabbit polyclonal to DGCR8
Description This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
Applications WB,IHC,IF,IP,FC
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Anti-DGCR8 Antibody
Immunogen Recombinant protein of human DGCR8
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 86 kDa
Database Links
Alternative Names DGCR8Microprocessor complex subunit DGCR8 antibodyDiGeorge syndrome critical region 8DGCR8 antibodyC22orf12 antibodyDGCRK6 antibodyLP4941
Function Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis, Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus, Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.
Cellular Localization Nucleus.
Tissue Specificity Ubiquitously expressed.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed