Anti-DHCR24 Antibody

Rs. 45,619.00
SKU stj27355

General Information

Product name Anti-DHCR24 Antibody
Short Description Rabbit polyclonal to DHCR24
Description This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-DHCR24 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.1 kDa
Database Links
Alternative Names DHCR24Delta(24 antibody-sterol reductase DHCR24 antibodyKIAA0018
Function Catalyzes the reduction of the Delta-24 double bond of sterol intermediates, Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress, Also protects against amyloid-beta peptide-induced apoptosis.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord, low expression in heart, uterus and prostate, undetectable in blood cells, in the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons, in brains affected by alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
Swiss-Prot Key

 

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