Anti-DHFR Antibody

Rs. 45,619.00
SKU stj23375

General Information

Product name Anti-DHFR Antibody
Short Description Rabbit polyclonal to DHFR
Description Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-DHFR Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human DHFR (NP_000782.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 21.5 kDa
Database Links
Alternative Names DHFRDihydrofolate reductase DHFR
Function Key enzyme in folate metabolism, Contributes to the de novo mitochondrial thymidylate biosynthesis pathway, Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis, Binds its own mRNA and that of DHFR2.
Cellular Localization Mitochondrion
Tissue Specificity Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood, expression is higher in the adult brain than in the fetal brain.
Swiss-Prot Key

 

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