Anti-DIO3 Antibody

Rs. 45,619.00
SKU stj28980

General Information

Product name Anti-DIO3 Antibody
Short Description Rabbit polyclonal to DIO3
Description The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-DIO3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 70-170 of human DIO3 (NP_001353.4).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.9 kDa
Database Links
Alternative Names DIO3Thyroxine 5-deiodinase DIO3 antibodyITDI3 antibodyTXDI3
Function Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine), RT3 and T2 are inactive metabolites, May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones, Can regulate circulating fetal thyroid hormone concentrations throughout gestation, Essential role for regulation of thyroid hormone inactivation during embryological development.
Cellular Localization Cell membrane
Tissue Specificity Expressed in placenta and several fetal tissues
Swiss-Prot Key

 

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