Anti-DISC1 Antibody

Rs. 45,619.00
SKU stj27683

General Information

Product name Anti-DISC1 Antibody
Short Description Rabbit polyclonal to DISC1
Description This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-DISC1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DISC1 (NP_001158009.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 93.6 kDa
Database Links
Alternative Names DISC1Disrupted in schizophrenia 1 proteinDISC1 antibodyKIAA0457
Function Involved in the regulation of multiple aspects of embryonic and adult neurogenesis, Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus, Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance, Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation, Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A, Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development, Plays a role, together with PCNT, in the microtubule network formation.
Cellular Localization Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
Tissue Specificity Ubiquitous, highly expressed in the dentate gyrus of the hippocampus, also expressed in the temporal and parahippocampal cortices and cells of the white matter.
Swiss-Prot Key

 

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