Anti-Dkk-3 antibody

Rs. 50,211.00
SKU stj92720

General Information

Product name Anti-Dkk-3 antibody
Short Description
Description Rabbit polyclonal to Dkk-3.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:20000
Protein Name Anti-Dkk-3 antibody
Immunogen Synthesized peptide derived from human Dkk-3
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 45 kDa
Database Links
Alternative Names Dickkopf-related protein 3 antibody
Dickkopf-3 antibody
hDKK3 antibody
REIC antibody
UNQ258/PRO295 antibody
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease .
Cellular Localization Secreted.
Tissue Specificity Highest expression in heart, brain, and spinal cord.
Swiss-Prot Key

 

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