Anti-DLG4 Antibody

Rs. 50,211.00
SKU stj27954

General Information

Product name Anti-DLG4 Antibody
Short Description Rabbit polyclonal to DLG4
Description This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications IF
Dilution range IF 1:50 - 1:200
Protein Name Anti-DLG4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DLG4 (NP_001356.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 80.5 kDa
Database Links
Alternative Names DLG4Disks large homolog 4 antibodyPostsynaptic density protein 95 antibodyPSD-95 antibodySynapse-associated protein 90 antibodySAP-90 antibodySAP90DLG4 antibodyPSD95
Function Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels, Required for synaptic plasticity associated with NMDA receptor signaling, Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons, May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly, May regulate the intracellular trafficking of ADR1B, Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.
Cellular Localization Cell membrane
Tissue Specificity Brain
Swiss-Prot Key

 

You recently viewed

Clear recently viewed