Anti-DMP1 Antibody

Rs. 45,619.00
SKU stj28009

General Information

Product name Anti-DMP1 Antibody
Short Description Rabbit polyclonal to DMP1
Description Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-DMP1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human DMP1 (NP_004398.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 55.8 kDa
Database Links
Alternative Names DMP1Dentin matrix acidic phosphoprotein 1 antibodyDMP-1 antibodyDentin matrix protein 1DMP1
Function May have a dual function during osteoblast differentiation, In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin, During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Cellular Localization Nucleus.
Tissue Specificity Expressed in tooth particularly in odontoblast, ameloblast and cementoblast
Swiss-Prot Key

 

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