Anti-DNAJC10 Antibody

Rs. 61,689.00
SKU stj26861

General Information

Product name Anti-DNAJC10 Antibody
Short Description Rabbit polyclonal to DNAJC10
Description This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-DNAJC10 Antibody
Immunogen A synthetic Peptide of human DNAJC10
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 91.1 kDa
Database Links
Alternative Names DNAJC10DnaJ homolog subfamily C member 10 DNAJC10 antibodyERDJ5 antibodyUNQ495/PRO1012
Function Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins, Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR, Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1, Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate, Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
Cellular Localization Endoplasmic reticulum lumen
Tissue Specificity
Swiss-Prot Key

 

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