Anti-DNMT3B Antibody

Rs. 45,619.00
SKU stj29319

General Information

Product name Anti-DNMT3B Antibody
Short Description Rabbit polyclonal to DNMT3B
Description CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-DNMT3B Antibody
Immunogen Recombinant protein of human DNMT3B
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 95.8 kDa
Database Links
Alternative Names DNMT3BDNA antibodycytosine-5 antibody-methyltransferase 3B antibodyDnmt3bDNMT3B
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, May preferentially methylates nucleosomal DNA within the nucleosome core region, May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation, Seems to be involved in gene silencing (By similarity), In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs, Function as transcriptional corepressor by associating with ZHX1, Required for DUX4 silencing in somatic cells.
Cellular Localization Nucleus
Tissue Specificity Ubiquitous
Swiss-Prot Key

 

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