Anti-DOCK 180 antibody

Rs. 50,211.00
SKU stj92756

General Information

Product name Anti-DOCK 180 antibody
Short Description
Description Rabbit polyclonal to DOCK 180.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-DOCK 180 antibody
Immunogen Synthesized peptide derived from human DOCK 180
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 215 kDa
Database Links
Alternative Names Dedicator of cytokinesis protein 1 antibody
180 kDa protein downstream of CRK antibody80 antibody
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen . Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 .
Cellular Localization Cytoplasm Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.
Tissue Specificity Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Swiss-Prot Key

 

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