Anti-DR1 Antibody

Rs. 45,619.00
SKU stj28983

General Information

Product name Anti-DR1 Antibody
Short Description Rabbit polyclonal to DR1
Description This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-DR1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 19.4 kDa
Database Links
Alternative Names DR1Protein Dr1 antibodyDown-regulator of transcription 1 antibodyNegative cofactor 2-beta antibodyNC2-beta antibodyTATA-binding protein-associated phosphoproteinDR1
Function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes, This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP, Can bind to DNA on its own, Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF