Anti-DTNBP1 Antibody

Rs. 45,619.00
SKU stj23439

General Information

Product name Anti-DTNBP1 Antibody
Short Description Rabbit polyclonal to DTNBP1
Description This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Anti-DTNBP1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human DTNBP1 (NP_115498.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39.5 kDa
Database Links
Alternative Names DTNBP1Dysbindin antibodyBiogenesis of lysosome-related organelles complex 1 subunit 8 antibodyBLOC-1 subunit 8 antibodyDysbindin-1 antibodyDystrobrevin-binding protein 1 antibodyHermansky-Pudlak syndrome 7 protein antibodyHPS7 proteinDTNBP1 antibodyBLOC1S8 antibodyMy031
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes, In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals, The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension, Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function, Plays a role in synaptic vesicle trafficking and in neurotransmitter release, Plays a role in the regulation of cell surface exposure of DRD2, May play a role in actin cytoskeleton reorganization and neurite outgrowth, May modulate MAPK8 phosphorylation, Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release, Regulates the expression of SYN1 through binding to its promoter, Modulates prefrontal cortical activity via the dopamine/D2 pathway.
Cellular Localization Cytoplasm.
Tissue Specificity Detected in brain, in neurons and in neuropil, isoform 1 is expressed in the cerebral cortex, and hippocampal frontal (hf), specific expression in the posterior half of the superior temporal gyrus (pstg), higher expression of isoform 2 and 3 in the hf than in the pstg while isoform 1 shows no difference in expression in these areas, in the hf, detected in dentate gyrus (dg) and in pyramidal cells of hippocampus ca2 and ca3 (at protein level), expressed in all principal neuronal populations of the hf, namely pyramidal neurons in the subiculum and ca1-3, granule cells in the dense cell layer of the dg (dgg), and polymorph cells in the hilus of the dg (dgh), maximal levels in ca2, ca3, and dgh, isoform 2 not expressed in the cerebral cortex.
Swiss-Prot Key

 

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