Anti-DTX1 Antibody

Rs. 57,098.00
SKU stj72066

General Information

Product name Anti-DTX1 Antibody
Short Description Goat polyclonal to DTX1
Description
Applications ELISA
Dilution range
Protein Name Anti-DTX1 Antibody
Immunogen internal region (near N Terminus)
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 67.4 kDa
Database Links
Alternative Names DTX1E3 ubiquitin-protein ligase DTX1 DTX1
Function Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity), Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context, Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1, Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation, Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1,
Cellular Localization Cytoplasm, Nucleus,
Tissue Specificity Widely expressed, strongly expressed in blood vessel, also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles, expressed in mzb cells and developing b- and t-cells,
Swiss-Prot Key

 

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