Anti-DYNLT1 Antibody

Rs. 45,619.00
SKU stj23453

General Information

Product name Anti-DYNLT1 Antibody
Short Description Rabbit polyclonal to DYNLT1
Description This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Anti-DYNLT1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human DYNLT1 (NP_006510.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 12.5 kDa
Database Links
Alternative Names DYNLT1Dynein light chain Tctex-type 1 antibodyProtein CW-1 antibodyT-complex testis-specific protein 1 homologDYNLT1 antibodyTCTEL1 antibodyTCTEX-1 antibodyTCTEX1
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function, Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules, Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia, May also be a accessory component of axonemal dynein
Cellular Localization Golgi apparatus
Tissue Specificity Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon, expressed in lung endothelial and smooth muscle cells (at protein level).
Swiss-Prot Key

 

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