Anti-E-cadherin antibody

Rs. 50,211.00
SKU stj92819

General Information

Product name Anti-E-cadherin antibody
Short Description Rabbit polyclonal to E-cadherin.
Description E-cadherin is a protein encoded by the CDH1 gene which is approximately 97,4 kDa. E-cadherin is localised to the cell membrane and Golgi apparatus. It is involved in cell junction organization, ERK signalling and apoptotic cleavage of cellular proteins. It is a calcium-dependent cell-cell adhesion protein that is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is also a ligand for integrin alpha-E/beta-7. E-cadherin is expressed in non-neural epithelial tissues. Mutations in the CDH1 gene may result in endometrial cancer and breast cancer. stj92819 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of E-cadherin protein.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-E-cadherin antibody
Immunogen Synthesized peptide derived from human E-cadherin
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 97 kDa
Database Links
Alternative Names Cadherin-1 antibody
CAM 120/80 antibody
Epithelial cadherin antibody
Uvomorulin antibody
CD antigen CD324 antibody
E-Cad/CTF1 antibody
E-Cad/CTF2 antibody
E-Cad/CTF3 antibody
CDHE antibody
UVO antibody
Function Cadherins are calcium-dependent cell adhesion proteins . They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells . Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Cellular Localization Cell junction Cell membrane. Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Tissue Specificity Non-neural epithelial tissues.
Swiss-Prot Key

 

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