Anti-E2F1 Antibody

Rs. 61,689.00
SKU stj29780

General Information

Product name Anti-E2F1 Antibody
Short Description Rabbit polyclonal to E2F1
Description The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-E2F1 Antibody
Immunogen A synthetic peptide of human E2F1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.9 kDa
Database Links
Alternative Names E2F1Transcription factor E2F1 antibodyE2F-1 antibodyPBR3 antibodyRetinoblastoma-associated protein 1 antibodyRBAP-1 antibodyRetinoblastoma-binding protein 3 antibodyRBBP-3 antibodypRB-binding protein E2F-1E2F1 antibodyRBBP3
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication, The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase, E2F1 binds preferentially RB1 in a cell-cycle dependent manner, It can mediate both cell proliferation and TP53/p53-dependent apoptosis, Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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