Anti-EAT-2 antibody

Rs. 50,211.00
SKU stj92816

General Information

Product name Anti-EAT-2 antibody
Short Description
Description Rabbit polyclonal to EAT-2.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-EAT-2 antibody
Immunogen Synthesized peptide derived from human EAT-2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 15.297 kDa
Database Links
Alternative Names SH2 domain-containing protein 1B antibody
EWS/FLI1-activated transcript 2 antibody
EAT2 antibody
Function Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 . In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation . Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling . In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse . Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation .
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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