Anti-EDN3 Antibody

Rs. 45,619.00
SKU stj26165

General Information

Product name Anti-EDN3 Antibody
Short Description Rabbit polyclonal to EDN3
Description The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-EDN3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 17-187 of human EDN3 (NP_996917.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 25.5 kDa
Database Links
Alternative Names EDN3Endothelin-3 antibodyET-3 antibodyPreproendothelin-3 antibodyPPET3EDN3
Function Endothelins are endothelium-derived vasoconstrictor peptides
Cellular Localization Secreted
Tissue Specificity Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
Swiss-Prot Key

 

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