Anti-EFNB2 Antibody

Rs. 45,619.00
SKU stj27636

General Information

Product name Anti-EFNB2 Antibody
Short Description Rabbit polyclonal to EFNB2
Description This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:10 - 1:100
Protein Name Anti-EFNB2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 28-229 of human EFNB2 (NP_004084.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.9 kDa
Database Links
Alternative Names EFNB2Ephrin-B2 antibodyEPH-related receptor tyrosine kinase ligand 5 antibodyLERK-5 antibodyHTK ligand antibodyHTK-LEFNB2 antibodyEPLG5 antibodyHTKL antibodyLERK5
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development, Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4, Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration, EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells, May play a role in constraining the orientation of longitudinally projecting axons.
Cellular Localization Membrane
Tissue Specificity Lung and kidney
Swiss-Prot Key

 

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