Anti-EIF2S3 Antibody

Rs. 45,619.00
SKU stj28664

General Information

Product name Anti-EIF2S3 Antibody
Short Description Rabbit polyclonal to EIF2S3
Description The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-EIF2S3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 173-472 of human EIF2S3 (NP_001406.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51.1 kDa
Database Links
Alternative Names EIF2S3Eukaryotic translation initiation factor 2 subunit 3 antibodyEukaryotic translation initiation factor 2 subunit gamma X antibodyeIF-2-gamma X antibodyeIF-2gXEIF2S3 antibodyEIF2G
Function As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis, In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation, This step is followed by mRNA binding to form the 43S pre-initiation complex, Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex, In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity), Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
Cellular Localization
Tissue Specificity Expressed in testis, brain, liver and muscle.
Swiss-Prot Key

 

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