General Information
| Product name | Anti-eIF3L antibody |
|---|---|
| Short Description | |
| Description | Rabbit polyclonal to eIF3L. |
| Applications | WB,IF,ELISA |
| Dilution range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:20000 |
| Protein Name | Anti-eIF3L antibody |
| Immunogen | Synthesized peptide derived from human eIF3L |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human,Mouse |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 67 kDa |
| Database Links | |
| Alternative Names | Eukaryotic translation initiation factor 3 subunit L antibody eIF3l antibody Eukaryotic translation initiation factor 3 subunit 6-interacting protein antibody Eukaryotic translation initiation factor 3 subunit E-interacting protein antibody EIF3EIP antibody EIF3S6IP antibody HSPC021 antibody HSPC025 antibody MSTP005 antibody |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 . |
| Cellular Localization | Cytoplasm |
| Tissue Specificity | |
| Swiss-Prot Key |
