Anti-eIF3L antibody

Rs. 50,211.00
SKU stj92876

General Information

Product name Anti-eIF3L antibody
Short Description
Description Rabbit polyclonal to eIF3L.
Applications WB,IF,ELISA
Dilution range WB 1:500-1:2000IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-eIF3L antibody
Immunogen Synthesized peptide derived from human eIF3L
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 67 kDa
Database Links
Alternative Names Eukaryotic translation initiation factor 3 subunit L antibody
eIF3l antibody
Eukaryotic translation initiation factor 3 subunit 6-interacting protein antibody
Eukaryotic translation initiation factor 3 subunit E-interacting protein antibody
EIF3EIP antibody
EIF3S6IP antibody
HSPC021 antibody
HSPC025 antibody
MSTP005 antibody
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 .
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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