Anti-ELF4 Antibody

Rs. 45,619.00
SKU stj29260

General Information

Product name Anti-ELF4 Antibody
Short Description Rabbit polyclonal to ELF4
Description The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.
Applications IF
Dilution range IF 1:50 - 1:100
Protein Name Anti-ELF4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ELF4 (NP_001412.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 70.7 kDa
Database Links
Alternative Names ELF4ETS-related transcription factor Elf-4 antibodyE74-like factor 4 antibodyMyeloid Elf-1-like factorELF4 antibodyELFR antibodyMEF
Function Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3', Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene, Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity), Also transactivates the PRF1 promoter in natural killer (NK) cells, Plays a role in the development and function of NK and NK T-cells and in innate immunity, Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity), Controls cell senescence in a p53-dependent manner, Can also promote cellular transformation through inhibition of the p16 pathway.
Cellular Localization Nucleus, PML body.
Tissue Specificity Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines, moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon, lower levels of expression in jurkat t-cells and other t-cell lines and no expression in brain.
Swiss-Prot Key

 

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