Anti-TCEB2 Antibody

Rs. 45,619.00
SKU stj27315

General Information

Product name Anti-TCEB2 Antibody
Short Description Rabbit polyclonal to ELOB
Description This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Applications WB,IP
Dilution range WB 1:500 - 1:2000
IP 1:20 - 1:50
Protein Name Anti-TCEB2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human TCEB2 (NP_009039.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 13.1 kDa
Database Links
Alternative Names ELOBElongin-B antibodyEloB antibodyElongin 18 kDa subunit antibodyRNA polymerase II transcription factor SIII subunit B antibodySIII p18 antibodyTranscription elongation factor B polypeptide 2ELOB antibodyTCEB2
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites, Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) , By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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