Anti-TCEB1 Antibody

Rs. 61,689.00
SKU stj28933

General Information

Product name Anti-TCEB1 Antibody
Short Description Rabbit polyclonal to ELOC
Description This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:50
Protein Name Anti-TCEB1 Antibody
Immunogen A synthetic Peptide of human TCEB1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 12.5 kDa
Database Links
Alternative Names ELOCElongin-C antibodyEloC antibodyElongin 15 kDa subunit antibodyRNA polymerase II transcription factor SIII subunit C antibodySIII p15 antibodyTranscription elongation factor B polypeptide 1ELOC antibodyTCEB1
Function SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites, Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) , By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Cellular Localization Nucleus
Tissue Specificity Overexpressed in prostate cancer cell line pc-3 and breast cancer cell line sk-br-3.
Swiss-Prot Key

 

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