Anti-EPCAM Antibody

Rs. 45,619.00
SKU stj25770

General Information

Product name Anti-EPCAM Antibody
Short Description Rabbit polyclonal to EPCAM
Description This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-EPCAM Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 40-260 of human EPCAM (NP_002345.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 34.9 kDa
Database Links
Alternative Names EPCAMEpithelial cell adhesion molecule antibodyEp-CAM antibodyAdenocarcinoma-associated antigen antibodyCell surface glycoprotein Trop-1 antibodyEpithelial cell surface antigen antibodyEpithelial glycoprotein antibodyEGP antibodyEpithelial glycoprotein 314 antibodyEGP314 antibodyhEGP314 antibodyKS 1/4 antigen antibodyKSA antibodyMajor gastrointestinal tumor-associated protein GA733-2 antibodyTumor-associated calcium signal transducer 1 antibodyCD antigen CD326EPCAM antibodyGA733-2 antibodyM1S2 antibodyM4S1 antibodyMIC18 antibodyTACSTD1 antibodyTROP1
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection, Plays a role in embryonic stem cells proliferation and differentiation, Up-regulates the expression of FABP5, MYC and cyclins A and E.
Cellular Localization Lateral cell membrane
Tissue Specificity Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (esc), levels rapidly diminish as soon as esc's differentiate (at protein levels), expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes, found on the surface of adenocarcinoma.
Swiss-Prot Key

 

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