Anti-EPHA1 Antibody

Rs. 61,689.00
SKU stj27214

General Information

Product name Anti-EPHA1 Antibody
Short Description Rabbit polyclonal to EPHA1
Description This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
Protein Name Anti-EPHA1 Antibody
Immunogen A synthetic peptide of human EPHA1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 108.1 kDa
Database Links
Alternative Names EPHA1Ephrin type-A receptor 1 antibodyhEpha1EPHA1 antibodyEPH antibodyEPHT antibodyEPHT1
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand, Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC, Plays also a role in angiogenesis and regulates cell proliferation, May play a role in apoptosis.
Cellular Localization Cell membrane
Tissue Specificity Overexpressed in several carcinomas
Swiss-Prot Key

 

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