Anti-EPHA2 Antibody

Rs. 45,619.00
SKU stj29263

General Information

Product name Anti-EPHA2 Antibody
Short Description Rabbit polyclonal to EPHA2
Description This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-EPHA2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 847-976 of human EPHA2 (NP_004422.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 108.3 kDa
Database Links
Alternative Names EPHA2Ephrin type-A receptor 2 EPHA2 antibodyECK
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells, Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway, May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration, During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues, Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development, Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance, With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Cellular Localization Cell membrane.
Tissue Specificity Expressed in brain and glioma tissue and glioma cell lines (at protein level), expressed most highly in tissues that contain a high proportion of epithelial cells, e,g, skin, intestine, lung, and ovary.
Swiss-Prot Key

 

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