Anti-EPHB4 Antibody

Rs. 57,098.00
SKU stj71348

General Information

Product name Anti-EPHB4 Antibody
Short Description Goat polyclonal to EPHB4
Description
Applications ELISA
Dilution range
Protein Name Anti-EPHB4 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 108.3 kDa
Database Links
Alternative Names EPHB4Ephrin type-B receptor 4 EPHB4 antibodyHTK antibodyMYK1 antibodyTYRO11
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration, EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells, Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis,
Cellular Localization Cell membrane
Tissue Specificity Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart, expressed in primitive and myeloid, but not lymphoid, hematopoietic cells, also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix,
Swiss-Prot Key

 

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