Anti-EPPIN Antibody

Rs. 45,619.00
SKU stj25677

General Information

Product name Anti-EPPIN Antibody
Short Description Rabbit polyclonal to EPPIN
Description This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-EPPIN Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-133 of human EPPIN (NP_065131.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 15.3 kDa
Database Links
Alternative Names EPPINEppin antibodyCancer/testis antigen 71 antibodyCT71 antibodyEpididymal protease inhibitor antibodyProtease inhibitor WAP7 antibodySerine protease inhibitor-like with Kunitz and WAP domains 1 antibodyWAP four-disulfide core domain protein 7EPPIN antibodySPINLW1 antibodyWAP7 antibodyWFDC7
Function Serine protease inhibitor that plays an essential role in male reproduction and fertility, Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
Cellular Localization Secreted, Cell surface.
Tissue Specificity In testis, expressed and secreted by sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa, expressed in the spermatogonia and the earliest preleptotene spermatocytes, in the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level), expressed specifically in epididymis and testis, isoform 2 is expressed only in the epididymis, weak expression is detected in myoid cells as well as spermatogenic cells.
Swiss-Prot Key

 

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