Anti-ERAP1 antibody

Rs. 50,211.00
SKU stj92971

General Information

Product name Anti-ERAP1 antibody
Short Description
Description Rabbit polyclonal to ERAP1.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-ERAP1 antibody
Immunogen Synthesized peptide derived from human ERAP1
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 107 kDa
Database Links
Alternative Names Endoplasmic reticulum aminopeptidase 1 antibody
ARTS-1 antibody
Adipocyte-derived leucine aminopeptidase antibody
A-LAP antibody
Aminopeptidase PILS antibody
Puromycin-insensitive leucyl-specific aminopeptidase antibody
PILS-AP antibody
Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator antibody
APPILS antibody
ARTS1 antibody
KIAA0525 antibody
UNQ584/PRO1154 antibody
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

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